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2例帕金森病患者服用多巴丝肼片(每片左旋多巴200 mg,苄丝肼50 mg)出现精神障碍。例1,70岁女性患者,初始服用多巴丝肼半片,1次/d。随后,剂量逐渐增至3片,1次/d。8个月后,患者出现压抑、烦躁,之后剂量增至4片,分2次服用。3周后,患者出现意识混乱、幻觉,自杀倾向。为此,剂量减至3片,分3次服用,患者症状消失。例2,65岁女性患者,服用多巴丝肼3片,1次/d。2个月后患者出现失眠、不安、乏力、压抑。剂量减至2片,1次/d。1周后患者症状消失。
Two patients with Parkinson’s disease took dopahydrazide tablets (200 mg levodopa per tablet, 50 mg benserazide) and developed mental disorders. Example 1, 70-year-old female patient, the initial taking half of basil hydrazine, 1 / d. Subsequently, the dose gradually increased to 3, 1 / d. After 8 months, the patient was depressed and irritable. After that, the dose was increased to 4 and taken in 2 doses. Three weeks later, the patient developed confusion, hallucinations, and suicidal tendencies. To this end, the dose was reduced to 3 tablets, taking 3 times, the patient’s symptoms disappear. Example 2,65-year-old female patients taking 3 doses of dobesidiazine, 1 time / d. 2 months after the patient insomnia, anxiety, fatigue, depression. Dose to 2 tablets, 1 time / d. After 1 week the patient’s symptoms disappeared.