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蛇毒抗栓酶是从我国浙江地区蝮蛇毒中提取制成具有抗凝、去纤、溶栓等作用的一种新药。临床上已用于治疗脑血栓、脉管炎等疾病,收到满意的疗效。但抗血栓作用机理及其与血栓素A_2(TXA_2)、前列环素(PGI_2)的关系;尚未见报道。本实验利用体外颈动脉—颈外静脉血流旁路法制成实验性血栓,观察蛇毒抗栓酶对血栓形成的
The snake venom antithrombotic enzyme is a new drug extracted from the venom of snake venom in Zhejiang Province, which has the functions of anticoagulation, defibrillation and thrombolysis. It has been used clinically to treat cerebral thrombosis, vasculitis and other diseases and has received satisfactory results. However, the antithrombotic mechanism and its relationship with thromboxane A 2 (TXA 2) and prostacyclin (PGI 2) have not yet been reported. In this experiment, experimental thrombus was made by bypassing external carotid artery-jugular vein bypass method to observe the effect of venom antithrombus enzyme on thrombosis.