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目的:观察止痛化癥胶囊联合抗生素治疗慢性盆腔炎气虚血瘀证的临床疗效。方法:将119例慢性盆腔炎气虚血瘀证患者纳入研究,按照随机数字表法分为对照组59例和观察组60例。对照组采用头孢曲松钠及替硝唑注射液治疗,观察组在对照组用药基础上加服止痛化癥胶囊。2组均用药14天。比较2组治疗前后症状积分、血液流变学指标[纤维蛋白原(Fib)、血浆黏度、全血黏度低切、全血黏度高切]及肿瘤坏死因子-α(TNF-α)、C-反应蛋白(CRP)水平的变化,观察2组临床疗效。结果:治疗后,2组下腹痛、腰骶痛、经量多及带下量多积分均较治疗前下降(P<0.05);观察组的4项症状积分均低于对照组(P<0.05)。治疗后,2组Fib、血浆黏度、全血黏度低切、全血黏度高切及CRP、TNF-α水平均较治疗前下降(P<0.05);观察组的4项血液流变学指标及CRP、TNF-α水平均较对照组下降更显著(P<0.05)。观察组总有效率95.00%,对照组总有效率79.66%,2组比较,差异有统计学意义(P<0.05)。结论:止痛化癥胶囊联合抗生素治疗慢性盆腔炎气虚血瘀证,能更有效地改善患者的症状、血液流变学指标及CRP、TNF-α水平,治疗效果优于抗生素。
Objective: To observe the clinical curative effect of analgesic capsule combined with antibiotics in the treatment of chronic pelvic inflammatory disease with qi deficiency and blood stasis syndrome. Methods: 119 cases of chronic pelvic inflammatory disease with Qi-deficiency and Blood Stasis syndrome were included in the study. According to the random number table, the patients were divided into control group (59 cases) and observation group (60 cases). The control group was treated with ceftriaxone sodium and tinidazole injection. The observation group was given the analgesic capsule on the basis of the control group. The two groups were treated for 14 days. Symptom scores, hemorheological indexes [fibrinogen (Fib), plasma viscosity, low whole blood viscosity, high whole blood viscosity] and tumor necrosis factor-α (TNF- Reactive protein (CRP) levels were observed in two groups of clinical efficacy. Results: After treatment, the lower abdominal pain, lumbosacral pain, the amount of more and the lower volume of multi-points decreased compared with those before treatment (P <0.05). The 4 symptom scores in the observation group were lower than those in the control group (P <0.05 ). After treatment, the levels of Fib, plasma viscosity, low whole blood viscosity, high whole blood viscosity, CRP and TNF-α in two groups were significantly lower than those before treatment (P <0.05). The four indexes of hemorheology, CRP, TNF-α levels were significantly lower than the control group (P <0.05). The total effective rate was 95.00% in the observation group and 79.66% in the control group. There was significant difference between the two groups (P <0.05). Conclusion: The combination of analgesic capsules and antibiotics in the treatment of chronic pelvic inflammatory disease with deficiency of Qi and blood stasis can effectively improve the symptoms, hemorheological indexes, levels of CRP and TNF-α in patients with chronic pelvic inflammatory disease. The treatment effect is better than that of antibiotics.