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目的探讨乙型肝炎病毒(HBV)感染与抗核抗体(ANA)的相关性及临床意义。方法将266例HBV感染者分为感染年限10年以下(Ⅰ组)及10年以上(Ⅱ组)2组,检测并分析其血清ANA、ANA谱和AST、ALT、TBIL、DBIL。另设76名健康体检者作为对照组。结果 (1)HBV感染Ⅰ组、Ⅱ组ANA阳性检测出率分别为26.0%、32.2%,差异有统计学意义(P<0.01);(2)HBV感染者ANA荧光模式以核颗粒型(25.6%)、核均质型(24.4%)、胞浆型(23.1%)为多见,ANA谱检出以抗-SS-A(28.1%)、抗-Ro-52(16.2%)、抗-u1-n RNP/Sm(13.5%)、抗-ds DNA(13.2)为多见。(3)血清AST、ALT、TBIL、DBIL结果,HBV感染者显著高于对照组,Ⅱ组ANA阳性者显著高于Ⅰ组ANA阳性者。结论 HBV感染可诱导自身免疫产生ANA,感染年限越长诱导越明显,检测ANA在HBV患者诊断及治疗中有一定临床意义。
Objective To investigate the relationship between hepatitis B virus (HBV) infection and antinuclear antibody (ANA) and its clinical significance. Methods 266 patients with HBV infection were divided into 2 groups (group Ⅰ, group Ⅰ) and group I (group Ⅱ) for more than 10 years. The serum ANA, ANA, AST, ALT, TBIL and DBIL were detected and analyzed. Another 76 health examination as a control group. Results (1) The positive rates of ANA in group Ⅰ and group Ⅱ of HBV infection were 26.0% and 32.2%, respectively (P <0.01). (2) (28.1%), anti-Ro-52 (16.2%), anti-SR-A u1-n RNP / Sm (13.5%), anti-ds DNA (13.2) is more common. (3) Serum AST, ALT, TBIL, DBIL results, HBV infection was significantly higher than the control group, ANA positive group Ⅱ was significantly higher than the A group ANA positive. Conclusion HBV infection can induce autoimmunity to produce ANA. The longer the infection period, the more obvious the induction is. The detection of ANA has certain clinical significance in the diagnosis and treatment of HBV.