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五十年代中期,英国应用链霉素、对氨柳酸和异菸肼治疗肺结核获得高疗效,已达到所谓“百分之百治疗成功”。但是还存在着下列诸问题:①治疗期两年以上;②每日用药2～4次;③强调卧床休息,加强营养和新鲜的空气;④每月照X光片,并作痰涂片和培养检查,痰培养阳性时,常规作药敏试验;⑤相当多患者作外科切除;⑥治疗后初期每月随访,以后间隔3～6个月随访数年。因此,结核病的治疗耗费人力、物力、财力甚大,发展中国家迫切需要继续探索更为简单、方便和价廉的有效治疗方案。
The mid-fifties, the United Kingdom the application of streptomycin, salicylic acid and isoniazid for the treatment of tuberculosis achieved high efficacy, has reached the so-called “one hundred percent treatment success.” But there are still the following problems: ① treatment period of two years or more; ② daily medication 2 to 4 times; ③ emphasis on bed rest, nutrition and fresh air; ④ monthly X-ray film, and sputum smear and Culture examination, sputum culture positive, the conventional drug susceptibility test; ⑤ a considerable number of patients for surgical resection; ⑥ initial follow-up after treatment, after a period of 3 to 6 months follow-up for several years. Therefore, the treatment of tuberculosis requires manpower, material and financial resources and there is an urgent need for developing countries to continue exploring effective treatment options that are simpler, more convenient and cheaper.