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探讨了小剂量肝素对呼吸窘迫综合征的治疗作用．将３６只Ｗｉｓｔａｒ大鼠随机分正常组、油酸组、治疗组３组．各组在乌拉坦麻醉下，用微量输液器从股静脉给药物，观察实验的不同时期动脉血氧分压、二氧碳分压和实验１２０ｍｉｎ的肺组织病理学及超微结构的变化．结果，治疗组氧分压下降、二氧化碳分压上升，与油酸组比较较轻，油酸组肺泡壁充血、水肿、坏死、白细胞浸润、肺泡腔内出血、水肿、透明膜形成，而治疗组的肺泡壁及肺泡腔内变化较轻、未见透明膜形成；观察油酸组的超微结构，示肺泡间隔明显增宽，Ⅰ型细胞水肿、坏死，Ⅱ型细胞板层小体排空明显，线粒体嵴排列紊乱及水肿，而治疗组的Ⅱ型细胞板层小体排空及线粒体变化较轻．
The therapeutic effect of low dose heparin on respiratory distress syndrome was discussed. 36 Wistar rats were randomly divided into normal group, oleic acid group and treatment group. The rats in each group were anesthetized with urethane, and drugs were administered from the femoral vein with a mini-infusion device. The changes of arterial oxygen pressure, dioxygen partial pressure and the histopathology and ultrastructure of the lung tissue during 120 min of the experiment were observed. As a result, the partial pressure of oxygen in the treatment group decreased, the partial pressure of carbon dioxide increased, and the oleic acid group was lighter. In the oleic acid group, alveolar wall congestion, edema, necrosis, leukocyte infiltration, alveolar hemorrhage, edema and hyaline membrane were formed. Alveolar wall and alveolar changes in the lighter, no transparent membrane formation; observe the ultrastructure of oleic acid group, showed significantly increased alveolar septa, type I cells edema, necrosis, type II cells lamellae obvious body emptying, Mitochondrial cristae were disordered and edematous, while the type Ⅱ cell platelet body emptying and mitochondrial changes in treatment group were lighter.