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采用放射免疫分析法,对33例重型乙肝(SH)(亚急性8例:SSH;慢性25例:CSH及13例急性乙肝(AH)、23例慢活乙肝(CAH)、10例无症状HBsAg携带者(ASC)和28个正常人的血清检测了聚人血清白蛋白受体(PHSA-Re),并同时对照观察了HBV的其它几项相关血清学指标。PHSA-Re在SH病人血清中的阳性率与AH、CAH和ASC组病人血清中阳性率无明显差别,但阳性P/N值明显低于CAH组(P<0.05)和ASC组(P<0.01)。说明PHSA-Re在SH病人血清中的存在状态不同于ASC和CAH病人,PHSA-Re与HBeAg、HBV-DNA有明显的相关性,但PHSA-Re与重型乙肝病人预后的关系尚待明确。
Thirty-three cases of severe hepatitis B (SH) (subacute 8 cases: SSH, chronic 25 cases: CSH and 13 cases of acute hepatitis B (AH), 23 cases of chronic hepatitis B (CAH), 10 cases of asymptomatic HBsAg Carriers (ASC) and 28 normal human serum poly-serum albumin receptor (PHSA-Re), and at the same time observed several other serological markers of HBV.PHSA-Re in SH patient serum (P <0.05), while the positive rate of P / N in CAH group and ASC group was significantly lower than that in ASC group (P <0.01), indicating that the positive rate of PHSA-Re in SH The patient’s serum is different from that of ASC and CAH patients. There is a clear correlation between PHSA-Re, HBeAg and HBV-DNA. However, the relationship between PHSA-Re and the prognosis of severe hepatitis B remains unclear.