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目的:研究信号转导和转录激活因子6(STAT6)在鼻息肉组织中的表达及其对嗜酸粒细胞(EOS)浸润聚集的作用,探讨其在鼻息肉发生中的可能作用。方法:选取符合纳入标准的鼻息肉患者手术切除标本(鼻息肉组)30例和同期单纯行鼻中隔偏曲矫正术中切除的下鼻甲组织(对照组)10例。采用免疫组织化学SP法检测2组下鼻甲黏膜中STAT6的表达。应用SPSS13.0软件进行统计学分析。结果:STAT6和EOS在鼻息肉组织中的表达明显高于下鼻甲,差异有统计学意义(P<0.05)。STAT6阳性细胞主要集中于鼻息肉的上皮细胞、腺体细胞和组织中浸润的炎性细胞的细胞质中。鼻息肉组中STAT6的表达与EOS浸润程度一致(P<0.01)。结论:STAT6在鼻息肉组织中的高表达及其对EOS浸润聚集的作用,可能与鼻息肉的发生和发展关系密切。
Objective: To investigate the expression of signal transducers and activators of transcription 6 (STAT6) in nasal polyps and its role in the invasion and aggregation of eosinophils (EOS), and to explore its possible role in the development of nasal polyps. Methods: Thirty patients with nasal polyps (nasal polyps) and 10 patients with inferior turbinate tissue (control group) resected by nasal septum deviation correction during the same period were enrolled. Immunohistochemical SP method was used to detect the expression of STAT6 in the inferior turbinate mucosa. Application SPSS13.0 software for statistical analysis. Results: The expression of STAT6 and EOS in nasal polyps was significantly higher than that in inferior turbinate (P <0.05). STAT6-positive cells are mainly concentrated in the epithelial cells of nasal polyps, in glandular cells and in the cytoplasm of infiltrating inflammatory cells in tissues. The expression of STAT6 in nasal polyps was consistent with the infiltration of EOS (P <0.01). Conclusion: The high expression of STAT6 in nasal polyps and its effect on the infiltration and aggregation of EOS may be closely related to the occurrence and development of nasal polyps.