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目的 :探讨 Ki- 6 7抗原在人脑胶质母细胞瘤中的表达及其预后作用。方法 :使用 S- P免疫组化方法检测 31例人脑胶质母细胞瘤标本中 Ki- 6 7抗原的表达。单因素使用 Kaplan- Meier法 ,多因素分析使用 COX比例风险模型进行预后分析。结果 :Ki- 6 7L I为 (8.0 7± 3.84) %。单因素及多因素分析均显示 Ki- 6 7指数是独立的预后因素。 Ki- 6 7指数≤ 2 .5 %与 >2 .5 %的患者生存期分别为 (4 6 .17± 17.2 1)月、(12 .43± 5 .0 1)月 ,P<0 .0 1。结论 :在人脑胶质母细胞瘤中 ,Ki- 6 7指数不同 ,其预后也有显著不同。 Ki- 6 7指数 >2 .5 %提示预后较差
Objective: To investigate the expression and prognosis of Ki- 6 7 in human glioblastoma. Methods: S-P immunohistochemical method was used to detect the expression of Ki-67 antigen in 31 specimens of human glioblastoma. Kaplan-Meier single-factor, multivariate analysis using the COX proportional hazard model for prognostic analysis. Results: Ki- 6 7L I was (8.07 ± 3.84)%. Univariate and multivariate analyzes showed that Ki- 6 7 index was an independent prognostic factor. The survival of patients with Ki- 6 7 index ≤ 2.5% and> 2.5% were (46.17 ± 17.21) months, (12.43 ± 5.11) months, P <0. 0 1. CONCLUSION: In human glioblastoma, the Ki-67 index is different and the prognosis is also significantly different. Ki- 6 7 Index> 2.5% suggests a poor prognosis