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目的:探讨腹腔镜微创对直肠癌患者肛肠动力学及血清癌胚抗原(CEA)、糖链抗原724(CA724)水平的影响。方法:选择2014年3月~2016年3月38例直肠癌患者为研究组及同期40例非肿瘤性肠息肉患者为对照组,比较术前两组的肛肠动力学指标(肛管静息压(ARP)、直肠静息压(RRP)、肛管最大收缩压(MSP)、直肠最大耐受容量(MTV),检测研究组术前及术后3 d、1、2周血清CEA、CA724水平,并观察临床疗效。结果:研究组术前ARP、RRP、MSP、MTV与对照组比较无明显差异(P>0.05),术后2、4周均明显降低(P<0.05),之后逐渐恢复,并在术后12周基本恢复至术前水平。研究组术后3 d血清CEA、CA724水平与术前比较无明显差异(P>0.05),术后1、2周均明显低于术前(P<0.05)。临床有效率为65.8%。结论:腹腔镜微创治疗直肠癌的疗效确切,可有效降低肿瘤标志物水平,虽对肛肠动力学有一定的影响,但可在短期内恢复正常。
Objective: To investigate the effects of laparoscopic minimally invasive surgery on anorectal dynamics and serum carcinoembryonic antigen (CEA) and carbohydrate antigen 724 (CA724) levels in patients with rectal cancer. Methods: 38 patients with rectal cancer from March 2014 to March 2016 were selected as study group and 40 patients with non-tumor intestinal polyps as control group. The anorectal dynamic parameters (anal resting pressure (RRP), maximal systolic pressure (MSP), maximal rectal capacity (MTV) of the rectum were measured in the study group. Serum levels of CEA and CA724 , And observe the clinical curative effect.Results: The preoperative ARP, RRP, MSP and MTV in the study group were not significantly different from the control group (P> 0.05), and were significantly lower at 2 and 4 weeks after operation (P <0.05) , And returned to the preoperative level at 12 weeks after operation.The level of serum CEA and CA724 in study group after 3 days was not significantly different from that before operation (P> 0.05), and was significantly lower than that before operation (P0.05) .The clinical effective rate was 65.8% .Conclusion: Laparoscopic minimally invasive treatment of rectal cancer is effective and can effectively reduce the level of tumor markers, although it may have an effect on anorectal dynamics, but it can be recovered in a short period of time normal.