乳腺癌的发生与阳性家族史、妊娠次数、接触雌激素、饮食类型和良性乳腺疾病有关 ,其中纤维腺瘤是妇女中最常见的良性乳腺肿瘤 ,发生在 2 0～ 5 0岁期间 ,Dupont提示它伴有乳腺癌的危机 ,但两者之间的关系仍不清楚。在乳腺癌 ,基因不稳定性 ,表现为杂合性丧失 (LOH)和 /或微卫 The occurrence of breast cancer is associated with a positive family history, number of pregnancies, estrogen exposure, type of diet, and benign breast disease, of which fibroadenoma is the most common benign breast tumor in women, occurring between 20 and 50 years of age. Dupont suggests It is accompanied by a crisis of breast cancer, but the relationship between the two is still unclear. In breast cancer, genetic instability, manifested as loss of heterozygosity (LOH) and / or microsatellite