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目的探讨前列腺癌患者根治术后病理分期、Gleason评分与术前血清PSA的相关性。方法收集香港中文大学附属威尔斯亲王医院泌尿外科2008年1月至2010年9月采用4-臂daVinci S-HD机器人外科手术系统施行前列腺根治性切除术的100例前列腺癌患者的临床资料数据,采用Spearman等级相关分析探讨根治术后病理分期、Gleason评分与术前血清PSA的相关性。结果患者PSA值与Gleason评分呈正相关(r=0.382,P<0.01),PSA值越高,Gleason评分值越高。PSA值与病理分期无明确的相关性(r=-0.073,P>0.05)。结论前列腺癌患者术前血清PSA与根治术后Gleason评分有关,与病理分期无明确的相关性。
Objective To investigate the correlation between Gleason score and preoperative serum PSA in patients with prostate cancer after radical operation. Methods Clinical data of 100 prostate cancer patients undergoing radical prostatectomy using a 4-arm daVinci S-HD robotic surgical system from January 2008 to September 2010 collected from the Department of Urology, Prince of Wales Hospital, The Chinese University of Hong Kong Spearman rank correlation analysis was used to investigate the correlation between Gleason score and preoperative serum PSA after radical operation. Results The PSA value was positively correlated with the Gleason score (r = 0.382, P <0.01). The higher the PSA value, the higher the Gleason score. There was no clear correlation between PSA and pathological stage (r = -0.073, P> 0.05). Conclusions The preoperative serum PSA in patients with prostate cancer is related to the Gleason score after radical operation and has no clear correlation with the pathological stage.