1．病例资料：患者,男,48岁。以“乏力、多饮、多尿、多食,伴消瘦4个月,加重1周”入院。既往有乙型肝炎和地中海贫血病史30年,无输血史,无血色病家族史,曾行“脾脏切除”治疗。查体：慢性贫血面容,全身皮肤黄染并有散在色素沉着,巩膜黄染,双手肝掌,男性乳房发育；肝右肋下3cm, 1. Case information: Patient, male, 48 years old. To “fatigue, drink more, more urine, more food, with weight loss 4 months, an increase of 1 week” admission. Past history of hepatitis B and thalassemia for 30 years, no blood transfusion, no family history of hemochromatosis, had “splenectomy” treatment. Physical examination: Chronic anemia face, body yellow skin with scattered pigmentation, yellowish sclera, liver palms hands, male breast development; Right rib 3cm,