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目的 评价他克莫司 (FK5 0 6 )与FK778或FK779联合应用预防大鼠心脏移植排斥反应的效果。方法 大鼠异位心脏移植后单独应用FK5 0 6、FK778和FK779进行免疫抑制治疗 ,并设联合用药组。结果 单独用药组与不用药对照组相比 ,移植心脏存活时间明显延长 ,FK779组尤其显著 ;联合用药组移植心脏存活时间不但比对照组明显延长 ,而且明显长于各药同剂量单用组 ,FK5 0 6与FK779合用组尤其显著。结论 FK5 0 6、FK778和FK779均有很强的免疫抑制效应 ,FK5 0 6与FK778或FK779联合应用具有较强的协同效应
Objective To evaluate the preventive effect of tacrolimus (FK506) combined with FK778 or FK779 in preventing cardiac allograft rejection in rats. Methods FK5 0 6, FK778 and FK779 alone were used in immunosuppressive therapy after heterotopic heart transplantation in rats, and the combination therapy group was established. Results Compared with the untreated control group, the survival time of transplanted heart was prolonged significantly, especially in FK779 group. The cardiac allograft survival time in combination group was significantly longer than that in control group and significantly longer than that in FK779 group 0 6 and FK779 combination group is particularly significant. Conclusion FK5 0 6, FK778 and FK779 all have strong immunosuppressive effects. The combination of FK5 0 6 with FK778 or FK779 has a strong synergistic effect