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一般而言,RNA病毒的复制,主要作用酶为RNA 聚合酶,所以RNA病毒不具有恒定的读码结构,其染 色体RNA复制时,碱基易被置换,故基因变异发生率 高。丙型肝炎病毒的RNA长度为9.4kb.呈单链(正 链)的RNA病毒,目前已知其有多种基因变异,按碱基 排列相同与否,至少可以分为Ⅰ、Ⅱ、Ⅲ、Ⅳ四个基因 型。而且同一种基因型的丙型肝炎病毒(HCV)又有许 多种碱基排列的多样性。与变异有密切关系的区域位 于编码病毒外壳区内的超变区(hypervariable region:
In general, RNA virus replication, the main role of the enzyme RNA polymerase, so the RNA virus does not have a constant reading frame structure, its chromosome RNA replication, the base is easy to be replaced, so the gene mutation rate is high. Hepatitis C virus RNA length of 9.4kb was single-stranded (positive) RNA virus, known to date there are a variety of genetic variations, the same base or not, can be divided into at least Ⅰ, Ⅱ, Ⅲ, Ⅳ four genotypes. And the same genotype of hepatitis C virus (HCV) and there are many kinds of base arrangement diversity. The regions closely related to the mutation are located in the hypervariable region