论文部分内容阅读
作者报告2例因服苯妥英钠引起的抑郁,并讨论其发病机理。例1:58岁、女,因上矢状窦血栓致颅内出血做左侧开颅术。术后出现强直阵挛性癫痫,右侧轻瘫,需服苯妥英钠300mg,每日2次,血药浓度达15.3μ/ml,症状控制,经1月增强理疗,生活能自理出院。1月后随访,患者诉食欲减退、疲倦、悲观,受检时不断流泪;乃转往精神病院会诊。于服抗抑郁药前,测苯妥英钠血浓度高达34.8μg/ml,将苯妥英钠减为300mg 每日1次,血药浓度降至6μg/ml,患者抑郁症状迅速消失。后每日服,400mg 及500mg 交替,血药浓度稳定在15.8μg/
The authors report two cases of depression due to phenytoin sodium and discuss its pathogenesis. Case 1: 58 years old, female, left craniotomy for intracranial hemorrhage due to superior sagittal sinus thrombosis. Postoperative tonic clonic epilepsy, right paralysis, need to take sodium phenytoin 300mg, 2 times a day, plasma concentration of 15.3μ / ml, symptom control, after January enhance physical therapy, life can take care of themselves discharged. After 1 month follow-up, patients complained of loss of appetite, fatigue, pessimism, constantly crying when examined; is transferred to psychiatric hospital for consultation. Before taking antidepressants, phenytoin sodium concentration was as high as 34.8μg / ml, phenytoin reduced to 300mg once a day, blood concentration dropped to 6μg / ml, the symptoms of depression in patients disappear rapidly. After the daily service, 400mg and 500mg alternating plasma concentration stabilized at 15.8μg /