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目的采用Meta分析方法对激光与放射治疗T1声门型喉癌的疗效进行评价。方法检索Medline/Pub Med、Web of knowledge、EMBASE、the Cochrane Library、the Wiley online library、Springer、Google及CNKI等数据库。通过制定纳入及排除标准,对文献进行筛选、质量评估,并提取相关数据。采用REevM Aan5.0软件对所纳入文献进行数据处理和综合分析。以早期喉癌患者的局部控制率、总体生存率、保喉率为观察指标,对比两种治疗的疗效。结果经筛选,最终对11篇符合要求的文献数据进行Meta分析。激光治疗与放射治疗相比可明显提高T1声门型喉癌患者的的保喉率(P<0.00);激光治疗组的总体生存率明显高于放射治疗组(P=0.04);激光治疗组的局部控制率与放疗组比较,差异无统计学意义(P=0.91)。通过偏差分析,总体5年生存率和保喉率的Meta分析均不存在明显的发表偏倚。结论激光治疗T1声门型喉癌的5年生存率及保喉率明显优于放射治疗组,但两者局部控制率无明显差异。
Objective To evaluate the efficacy of laser and radiotherapy in the treatment of T1 glottic laryngeal cancer by Meta-analysis. Methods The databases Medline / Pub Med, Web of knowledge, EMBASE, the Cochrane Library, the Wiley online library, Springer, Google and CNKI were searched. Through the establishment of inclusion and exclusion criteria, the literature screening, quality assessment, and extract the relevant data. Using REevM Aan5.0 software for the inclusion of the literature data processing and comprehensive analysis. To early laryngeal cancer patients with local control rate, overall survival rate, Paul laryngeal rate as an index to compare the efficacy of the two treatment. The results were screened, and ultimately meet the requirements of the 11 literature data Meta analysis. Compared with radiotherapy, laryngopharyngeal carcinoma of the larynx in T1 glotticus laryngeal cancer patients could significantly increase the laryngeal insufficiency rate (P <0.00). The overall survival rate of the laser treatment group was significantly higher than that of the radiotherapy group (P = 0.04) The local control rate compared with radiotherapy group, the difference was not statistically significant (P = 0.91). By deviation analysis, there was no obvious publication bias in the meta-analysis of the overall 5-year survival rate and laryngotracheal retention rate. Conclusion The laser treatment of T1 glottic laryngeal cancer 5-year survival rate and preservation of laryngeal rate was significantly better than the radiotherapy group, but the two local control rate was no significant difference.