论文部分内容阅读
目的:评价美沙拉嗪与帕罗西汀联用对溃疡性结肠炎(UC)伴抑郁症患者的临床疗效。方法:选取2013年6月—2016年5月间消化科确诊为溃疡性结肠炎伴抑郁症患者98例,将其分为对照组48例和观察组50例;对照组患者给予美沙拉嗪口服治疗,观察组患者在对照组基础上加用帕罗西汀口服治疗,比较两组患者治疗12周后脓血便、腹痛、腹泻等症状积分值,Baron内镜积分值及汉密顿抑郁量表(HAMD)评分值以及总有效率。结果:治疗后,观察组患者脓血便、腹痛、腹泻等症状积分值及Baron内镜积分值低于对照组(P<0.05),HAMD评分值低于对照组(P<0.05),总有效率高于对照组(P<0.05)。结论:采用美沙拉嗪与帕罗西汀联用治疗溃疡性结肠炎伴抑郁症患者,可改善患者负面情绪,且有助于临床疗效的提高。
Objective: To evaluate the clinical efficacy of mesalazine combined with paroxetine in the treatment of patients with ulcerative colitis (UC) and depression. Methods: A total of 98 patients with ulcerative colitis and depression diagnosed by Department of Gastroenterology from June 2013 to May 2016 were selected and divided into control group (48 cases) and observation group (50 cases). Patients in the control group were given mesalazine orally The patients in the observation group were treated with paroxetine orally on the basis of the control group. The scores of pus and blood stool, abdominal pain, diarrhea and other symptoms, Baron endoscopy scores and HAMD Scoring values and total effectiveness. Results: After treatment, the scores of pus and blood stool, abdominal pain and diarrhea and Baron endoscopy in the observation group were lower than those in the control group (P <0.05), and the HAMD score was lower than that in the control group (P <0.05). The total effective rate Higher than the control group (P <0.05). Conclusion: The combination of mesalazine and paroxetine in the treatment of patients with ulcerative colitis and depression can improve the negative emotions of patients and help to improve the clinical efficacy.