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目的 :探讨急性早幼粒细胞白血病 (APL)患者染色体异常与临床特点间的关系 ;方法 :对 2 2例APL患者进行染色体核型分析 ,将其分为t(1 5 ;1 7)阳性组与阴性组 ,并比较其临床特点 ;结果 :6例t(1 5 ;1 7)阴性的APL患者中有 5例在临床特点及全反式维甲酸 (ATPA)治疗效果上与t(1 5 ;1 7)阳性组相比无明显差异 ,但另一例t(1 5 ;1 7)阴性者用ATRA治疗一直未达完全缓解 (CR)。 1 6例t(1 5 ;1 7)阳性者在达CR后仍有 1 0例 (占 6 2 % )可查到t(1 5 ;1 7)存在 ;结论 :在ATRA诱导达CR后应及时、充分地巩固强化治疗 ,对t(1 5 ;1 7)阴性者应进行PML—RARα 融合基因的检测 ,根据基因检测结果决定治疗方案。
Objective: To investigate the relationship between chromosomal abnormalities and clinical features in patients with acute promyelocytic leukemia (APL). Methods: Twenty-two cases of APL patients were divided into t (15; 17) positive groups And the negative group, and compared their clinical features.Results: Of the 6 patients with t (15; 17) negative APL, 5 had no significant difference in clinical features and therapeutic effect of all-trans retinoic acid (ATPA) ; 1 7), there was no significant difference in the positive group, but another case of t (1 5; 1 7) negative treatment with ATRA has been less than complete remission (CR). 16 cases of t (15; 17) positive cases still had 10 cases (62.2%) after CR, and the presence of t (15; 17) was found. Conclusion: After ATRA induction of CR, Timely and fully to strengthen the intensive treatment, t (1; 5; 1 7) negative should be PML-RARα fusion gene test, according to the results of genetic testing to determine treatment options.