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小儿呕吐引起急性胃肠粘膜损伤是多种疾病的常见并发症,可引起水电解质紊乱,消化道出血,甚至穿孔,目前国内外治疗急性胃粘摸损伤的治疗常用西米替丁,维生素B6、思密达及止吐药多番立酮等。而西米替丁可抑制肝细胞色素P450氧化酶系统增加依赖这些酶代谢的药物的血清水平和潜在毒性,而法膜替丁的抗H2受体作用较西米替丁强,对肝脏P450酶系统几乎无影响。
Pediatric vomiting caused by acute gastrointestinal mucosal injury is a common complication of various diseases, can cause water and electrolyte disorders, gastrointestinal bleeding, or even perforation, the current treatment of acute gastric mucosal injury at home and abroad commonly used cimetidine, vitamin B6, Smecta and antiemetic drugs such as ketone ketone. Whereas cimetidine inhibits the serum levels and potential toxicity of the hepatocyte P450 oxidase system to drugs that rely on these enzymes, whereas the anti-H2 receptor effect of fomesirol is stronger than that of cimetidine on liver P450 enzyme The system has almost no effect.