论文部分内容阅读
本实验研究是在狗身上进行的,其目的是研究肽yy对胃酸分泌抑制的机制(方法从略)。材料和方法:选用17只杂种狗,体重16～22Kg,分为三组。第一组6只狗做胃瘘和十二指肠瘘;第二组5只狗做胃瘘、十二指肠瘘和巴甫洛夫小胃;第三组6只狗做胃瘘、十二指肠瘘和海登汉小胃。第一组静注2-脱氧葡萄糖(2-DG,75mg/kg),单用或并注肽yy(100、200或400pmol/kg·h)1小时,每间隔15分钟取胃液和血标本(分别检测酸度和胰多肽)。第二组经胃瘘注入10%肝浸出液(pH7.0.100ml/h,共2.5h),滴注1小时后,再输入两剂肽yy(200和400Pmol/
The experimental study is carried out in dogs, its purpose is to study the mechanism of peptide yy inhibition of gastric acid secretion (omitted). MATERIALS AND METHODS: Seventeen hybrid dogs were selected and weighed 16 to 22 kg and divided into three groups. The first group of 6 dogs did gastrostomy and duodenal fistula; the second group of 5 dogs did gastric fistula, duodenal fistula and Pavlov’s small stomach; the third group of 6 dogs did gastric fistula and ten Duodenal fistula and Heidenhain stomach. The first group was intravenously injected with 2-deoxyglucose (2-DG, 75 mg / kg) for 1 hour at a dose of 100, 1, 200 or 400 pmol / kg · h, with gastric juice and blood samples taken every 15 minutes Acidity and pancreatic polypeptide were tested separately). In the second group, 10% hepatic leachate (pH7.0.100ml / h, total 2.5h) was injected into the gastric fistula. One hour after the infusion, two more peptides, yy (200 and 400Pmol /