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主要组织相容性复合物(MHC)及免疫球蛋白超家族在免疫系统中起着重要作用,现在认为多态性 MHC 涉及到生殖行为和其它生理学反应.以前报道 Ig 相关识别结构直接参与受精作用。本文作者报道了精予与血细胞以一种型特异性方式相互反应,即精子与具有 HLA-DR 结构的血细胞反应,他认为淋巴细胞上的 HLA-DR 分子和精子上的 T_4样分子是这种型特异性相互反应的主要成份,其依据为:①精子与 HLA-DR 阳性细胞(外周血中 B细胞,单核细胞、激活的 T 细胞等)反应,并渗透进入这些细胞内,②抗 HLA-DR 或抗 T_4抗体可以抑制精子与 HLA-DR 阳性细胞反应,这些结果表明,哺乳动物精子与卵的识别和粘附涉及到 T_4分
The major histocompatibility complex (MHC) and the immunoglobulin superfamily play an important role in the immune system, and now it is thought that polymorphic MHC involves reproductive behavior and other physiological responses. It has previously been reported that Ig-related recognition structures are directly involved in fertilization . The authors report that neutrophil interacts with blood cells in a type-specific manner, that is, sperm react with hemocytes that have an HLA-DR structure. He believes that HLA-DR molecules on lymphocytes and T 4 -like molecules on sperm are Type specific interaction based on: ① sperm and HLA-DR positive cells (peripheral blood B cells, monocytes, activated T cells, etc.) react and penetrate into these cells, ② anti-HLA -DR or anti-T_4 antibody can inhibit the reaction of sperm with HLA-DR positive cells, these results show that mammalian sperm and egg recognition and adhesion involve T_4