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目的探讨果糖二磷酸钠治疗新生儿窒息后心肌损害的临床疗效。方法选取2013年7月—2015年7月内江市市中区妇幼保健院收治的140例新生儿窒息合并心肌损害患儿,随机分为对照组70例和观察组70例。两组患儿均予以常规治疗,观察组在常规治疗基础上给予果糖二磷酸钠治疗。比较两组患儿的临床疗效及心肌肌钙蛋白I(c Tn I)及肌酸激酶同工酶(CK-MB)水平。结果观察组总有效率高于对照组,差异有统计学意义(P<0.05);治疗前两组患儿c Tn I及CK-MB水平比较,差异无统计学意义(P>0.05),治疗后观察组c Tn I及CK-MB水平低于对照组,差异有统计学意义(P<0.05)。结论果糖二磷酸钠协同治疗新生儿窒息后心肌损害的临床疗效显著,可有效降低c Tn I及CK-MB水平。
Objective To investigate the clinical efficacy of fructose-diphosphate in the treatment of neonatal asphyxia myocardial injury. Methods From July 2013 to July 2015, 140 cases of neonatal asphyxia and myocardial damage admitted to the MCH Hospital of Neijiang City were randomly divided into control group (70 cases) and observation group (70 cases). Two groups of children were given conventional treatment, the observation group on the basis of conventional treatment given fructose diphosphate treatment. The clinical efficacy and the levels of cardiac troponin I (cTn I) and creatine kinase MB (CK-MB) in both groups were compared. Results The total effective rate in the observation group was higher than that in the control group (P <0.05). There was no significant difference in cTn I and CK-MB levels between the two groups before treatment (P> 0.05) After treatment, the levels of cTn I and CK-MB in the observation group were lower than those in the control group, with statistical significance (P <0.05). Conclusion The synergistic effect of fructose-2-phosphate in the treatment of myocardial damage after neonatal asphyxia is significant, which can effectively reduce the levels of cTn I and CK-MB.