上皮性卵巢癌是死亡率最高的妇科恶性肿瘤,对其发生、发展、转移、耐药和复发等相关机制的研究具有非常重要的意义。DNA甲基化作为表观遗传的一种主要方式,协助调控基因表达。多种基因的异常和/或低甲基化显示出与卵巢癌发生、发展、治疗和预后有密切的关系,深入研究其作用机制将有助于卵巢癌早期诊断、辅助治疗和预后判断。综述DNA甲基化及其生物学功能、DNA异常甲基化在恶性肿瘤发生中的作用及其在卵巢癌方面的最新研究进展。 Epithelial ovarian cancer is the highest mortality of gynecological malignancies, its occurrence, development, metastasis, drug resistance and recurrence and other related mechanisms of great significance. DNA methylation as a major form of epigenetic, to help regulate gene expression. Abnormality and / or hypomethylation of multiple genes have been shown to be closely related to the occurrence, development, treatment and prognosis of ovarian cancer. Further study of its mechanism of action will be helpful for the early diagnosis, adjuvant therapy and prognosis of ovarian cancer. This review summarizes the role of DNA methylation and its biological functions in DNA methylation in the development of malignant tumors and its recent progress in ovarian cancer.