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为研究系统性红斑狼疮 ( SL E)患者红细胞补体受体 型 ( CR1)与淋巴细胞功能相关抗原 - 1( L FA- 1)表达及其与病情发展的关系 ,对 36例 SL E患者进行了红细胞 CR1分子定量测定及 CD1 1 a ( L FA- 1中的一种 )测定。结果SL E活动期、稳定期患者和正常人单个红细胞表面 CR1数目依次升高 ,且三者间两两比较有显著统计学意义 ( P <0 .0 1) ;SL E活动期淋巴细胞表面 CD1 1 a表达和稳定期患者比较明显增高 ( P<0 .0 1) ;SL E患者红细胞 CR1数量与淋巴细胞表面 CD1 1 a呈负相关 ( r =- 0 .891,P <0 .0 1) ,其红细胞 CR1与狼疮活动积分呈负相关 ( r=- 0 .6 0 1,P <0 .0 5 )。认为对 SL E患者进行红细胞 CR1与 L FA- 1表达测定 ,对临床诊断和病情判断有重要参考价值
To investigate the relationship between erythrocyte complement receptor (CR1) and lymphocyte function-associated antigen-1 (L FA-1) expression in patients with systemic lupus erythematosus (SLE) and its relationship with disease progression, 36 patients with SL E RBC erythrocyte quantification and CD1 1 a (one of L FA-1) assays. Results The number of CR1 on the surface of single erythrocytes in SL E active stage and stable one was higher than that in the normal one (P <0.01), and the expression of CD1 on the surface of SL E active lymphocytes (P <0.01). The number of erythrocyte CR1 in SL E patients was negatively correlated with CD1 1 a on the surface of lymphocytes (r = - 0.891, P <0.01) . The erythrocyte CR1 was negatively correlated with the activity score of lupus (r = - 0.601, P <0.05). It is considered that the determination of erythrocyte CR1 and L FA-1 expression in SL E patients has important reference value for clinical diagnosis and disease judgment