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为了观察补肾健脾中药对去卵巢大鼠骨矿含量、骨密度及其生物力学的影响 ,给其防治绝经后骨质疏松症提供实验依据。取 10月龄SD雌性大鼠 40只 ,随机分为模型组、正常对照组、阳性对照组、中药骨必康组 ,每组 10只 ,正常对照组行假手术。其余3组行完整双侧卵巢摘除术。术后第 3天开始灌胃给药 ,连续用药满 12周后处死 ,分离出L2 椎体及左侧股骨 ,测量其骨矿含量、骨密度 ,并进行生物力学测试。结果表明中药骨必康能明显增加去卵巢大鼠的骨矿含量与骨密度 (P <0 .0 5 ) ,有效维持椎体的生物力学性能 ,并对股骨的结构力学性能也有一定的维持作用。
In order to observe the effect of Bushenjianpi herbs on bone mineral content, bone mineral density and biomechanics of ovariectomized rats, it provides experimental basis for prevention and treatment of postmenopausal osteoporosis. 40 SD female rats of 10 months of age were randomly divided into model group, normal control group, positive control group, and traditional Chinese medicine Bifikang group. There were 10 rats in each group. Normal control group received sham operation. The remaining 3 groups underwent complete bilateral ovariectomy. On the third postoperative day, the rats were given intragastric administration and were sacrificed after 12 consecutive weeks of drug administration. The L2 vertebral body and the left femur were separated, and their bone mineral content and bone density were measured, and biomechanical tests were performed. The results showed that Bifukang significantly increased bone mineral content and bone density in ovariectomized rats (P < 0.05), effectively maintained the biomechanical properties of the vertebral body, and also maintained the structural and mechanical properties of the femur. .