疟原虫利用血红蛋白有2个过程:(1)由体内的内肽酶分解血红蛋白分子的多肽链,继而由外肽酶将其分解至氨基酸后摄取;(2)将各肽酶的分解产物直接吸收加以利用。有报告认为内肽酶是一种酸性蛋白酶,但该酶对血红蛋白的反应机理尚不明确。为此我们从感染柏氏疟原虫的BALB/c小鼠的红细胞膜,提取了一种属于外肽酶的氨肽酶,将其 Plasmodium use hemoglobin has two processes: (1) by the endopeptidase in vivo decomposition of hemoglobin molecule polypeptide chain, followed by exopeptidase to break down into amino acids after intake; (2) the peptidase decomposition products directly absorbed Use it. It has been reported that endopeptidase is an acidic protease, but the reaction mechanism of the enzyme on hemoglobin is not yet clear. To this end, we extracted an aminopeptidase belonging to the exopeptidase from the erythrocyte membrane of BALB / c mice infected with Plasmodium berghei,