目的　研究阿托品对实验性近视形成的影响 .方法幼兔 5 3只 (7d) ,分 A,B,C3组 .A组 2 0只 ,单纯缝合眼睑 ;B组 1 7只 ,缝合眼睑 +玻璃体内注射阿托品 ;C组 1 6只 ,缝合眼睑 +玻璃体注射生理盐水 .均以右眼为实验眼 ,左眼为对照眼 .6 0 d用 A超测量每组双眼的前房深度、晶体厚度、玻璃体腔长度和眼轴长度 ,并计算玻璃体腔长度 /眼轴长度 ,同时进行病理学观察 .结果　在 A,C两组中实验眼产生相对性近视 ,两眼的玻璃体腔长度、眼轴长度和玻璃体腔长度 /眼轴长度间的差异均有高度显著的统计学意义 (P<0 .0 1 ) .而前房深度和晶体厚度无统计学差异 ,而 B组均无统计学差异 .巩膜胶原纤维在 A,C两组实验眼中明显变细 ,而在 B组中改变较轻 .结论　形觉剥夺能导致眼球的轴性延长 ,使眼球的形态学和组织学发生改变 ,其中玻璃体腔延长和玻璃体腔长度 /眼轴长度增大是其形态学原因 ,巩膜纤维的变细、延长是其病理学原因 ,而阿托品能部分阻止这些改变 Objective To study the effect of atropine on experimental myopia.Methods A total of 53 rabbits (7 days) were divided into groups A, B and C. A group of 20 rabbits with simple eyelid suture, group B with 17 rabbits, suture eyelid and vitreous Injection of atropine; C group of 16, suture eyelid + vitreous injection of saline, both with the right eye as the experimental eye, the left eye as the control eye .60 days with A ultrasound measured anterior chamber depth of each binocular, crystal thickness, glass Length of the body cavity and length of the ocular axis, and calculate the length of the vitreous cavity / length of the ocular axis, at the same time the pathological observation.Results There were relative myopia in the experimental eye in both groups A and C, the length of the vitreous cavity, axial length and glass There were significant differences between the length of the body cavity and the length of the axial length (P <0.01), while there was no significant difference between the depth of the anterior chamber and the thickness of the lens group, but there was no significant difference between the group B and the scleral collagen fibers In A, C two groups of experimental eyes significantly thinner, and lighter changes in group B. Conclusion Form deprivation can lead to the axial extension of the eye, the eye morphology and histology changes, including vitreous cavity extension and glass Body cavity length / axial length increases is its shape Studies reason, thinning of the fibrous sclera, is extended pathology reasons, atropine partially prevented these changes