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1例29岁男性患者,因慢性乙型病毒性肝炎给予干扰素α-2b300万IU,隔日1次肌内注射。4个月后因效果欠佳,加用替比夫定600mg,1次/d口服,两药联用第9个月患者出现肌肉酸痛,第11个月停用两药。第15个月出现恶心、呕吐,腹泻,随后又出现大便秘结及餐后上腹痛入院。实验室检查:pH值7.25,血乳酸11mmol/L,血清淀粉酶305U/L。给予补液、抗感染、纠正酸中毒等治疗。入院6d后症状好转。
One 29-year-old man with interferon alpha-2b, 3 million IU for chronic hepatitis B was injected intramuscularly on alternate days. After 4 months because of ineffective, plus telbivudine 600mg, 1 / d orally, the two drugs combined with the first 9 months of patients with muscle soreness, the first two months to disable the two drugs. The 15th month showed nausea, vomiting and diarrhea, followed by constipation and postprandial upper abdominal pain. Laboratory tests: pH 7.25, blood lactate 11mmol / L, serum amylase 305U / L. Give rehydration, anti-infection, to correct acidosis and other treatment. 6d after admission symptoms improved.