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[目的]观察雷马Ⅱ型贴膏对动物皮肤给药的毒性作用,探讨其皮肤用药的安全性。[方法]对健康家兔进行皮肤刺激实验并进行评分,对健康家兔进行皮肤急性毒性实验并观察有无急性毒性反应出现,对健康豚鼠进行皮肤过敏实验并进行评分,对wistar大鼠进行慢性毒性实验并观察其一般状态、体重、血常规及生化指标、脏器指数、组织病理变化。[结果]雷马Ⅱ型贴膏对家兔完整皮肤无刺激性,对破损皮肤有轻度刺激性,但在给药后24小时消失;对家兔完整皮肤及破损皮肤未引起急性毒性反应;对豚鼠完整皮肤无致敏作用;对wistar大鼠一般状态、体重、血常规及生化指标、脏器指数、组织病理变化均未产生明显影响,未出现慢性毒性反应。[结论]雷马Ⅱ型贴膏用于皮肤给药安全、无毒。
[Objective] To observe the toxic effect of Rayma Ⅱ plaster on the skin of animals and explore the safety of its skin medication. [Method] The healthy rabbits were subjected to skin irritation test and scored. The healthy rabbits were subjected to acute skin toxicity test and the presence or absence of acute toxicity was observed. Skin allergy test was conducted on healthy guinea pigs and scored. Wistar rats were subjected to chronic Toxicity tests were performed and their general status, body weight, blood and biochemical parameters, organ index and histopathological changes were observed. [Result] RMA Ⅱ was not irritating to intact skin of rabbits and slightly irritating to damaged skin, but disappeared 24 hours after dosing. No acute toxicity was observed on intact and damaged skin of rabbits. No sensitization to the intact skin of guinea pigs; no significant effect on the general state, body weight, blood and biochemical indexes, organ index and histopathological changes in wistar rats, no chronic toxicity occurred. [Conclusion] Rayma Ⅱ plaster is safe and nontoxic for skin administration.