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伤寒在发展中国家仍有散发或流行,耐药菌株发生率上升、耐药谱增加,使治疗发生困难.我院近年收治耐药伤寒患儿36例,对其临床表现、T淋巴细胞亚群变化、细菌耐药谱及菌株质粒进行了观察,并于1年后对部分患儿随访肥达氏反应消长情况,报道如下.1 资料与方法1.1对象 36例均经血、粪便及骨髓培养伤寒杆菌阳性而确诊.其中28例血培养阳性、9例粪便培养及2例骨髓培养阳性.6例血及粪便两种标本培养均阳性、1例骨髓及粪便培养阳性、1例血及骨髓培养阳性.
Typhoid fever in developing countries are still circulating or epidemic, the incidence of drug-resistant strains increased resistance spectrum increased, making the treatment difficult.Our hospital in recent years admitted 36 cases of drug-resistant typhoid fever, its clinical manifestations, T lymphocyte subsets Changes, bacterial resistance spectrum and plasmid strains were observed, and in 1 year after the follow-up of some children Widal reaction growth reported as follows.1 Materials and Methods 1.1 Object 36 cases of blood, feces and bone marrow culture of Salmonella typhi Positive in 28 cases, positive in blood culture, positive in 9 cases of stool culture and 2 cases of bone marrow, positive in 6 cases of blood and stool, 1 case of bone marrow and stool culture positive, 1 case of blood and bone marrow culture positive.