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为了观察青蒿琥酯预防日本血吸虫感染的效果和优化服药方案，1996年4－11月，选择湖沼型血吸虫病重度流行的安徽省贵池市唐田乡2个村为试点。结果口服青蒿琥酯323人的粪检血吸虫卵阳性率为0．31％，无血吸虫急性感染发生；对照组323人的粪检血吸虫卵阳性率为9．60％，平均EPG为4．00±3．50，出现急性血吸虫感染1例。用药前后对肝、肾功能、网织红细胞和心电图检查未见明显变化。结果表明在感染季节每半个月口服青蒿琥酯1次，对湖沼型重度血吸虫病流行区人群有较好的预防作用。
In order to observe the effect of artesunate against Schistosoma japonicum infection and to optimize its medication regimen, from April to November 1996, 2 villages in Tangtian Township, Guichi, Anhui Province, with severe lakeshore schistosomiasis were selected as the pilot. Results The positive rate of OSTEV was 323 (323) and no acute infection with schistosomiasis. The positive rate of schistosopatho eggs in 323 control persons was 9.60% with an average EPG of 4.00 ± 3.50, 1 case of acute schistosome infection. Before and after treatment of liver, kidney function, reticulocyte and ECG showed no significant changes. The results showed that artesunate was given orally once every two months during the infection season, which had a good preventive effect on the population with severe schistosomiasis lakes.