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雄性小鼠灌胃雷公藤多甙２０、３０ｍｇ／ｋｇ，１４ｄ或２１ｄ均能引起精子损伤。六味地黄汤（剂量以ｇ生药／ｋｇ表示）以１５ｇ／ｋｇ或２５ｇ／ｋｇ灌胃能对抗雷公藤多甙以２０ｍｇ／ｋｇ灌胃１４ｄ所造成的精子损伤。通过对生育力的研究发现，雷公藤多甙以２０ｍｇ／ｋｇ灌胃雄性小鼠１４ｄ不能明显减少受孕雌性小鼠的只数，但能明显减少孕鼠的胎仔数。六味地黄汤分别以１５、２５ｇ／ｋｇ灌胃均能对抗雷公藤多甙降低胎仔数的作用。拆方研究表明：六味地黄汤全方与三泻（泽泻、丹皮、茯苓）、三补（熟地、山药、山茱萸）均有明显对抗雷公藤多甙损伤精子的作用。三泻与全方作用相当，而三补作用稍弱。
Male mice fed with tripterygium wilfordii 20, 30 mg/kg, 14d or 21d can cause sperm damage. Liuwei Dihuang Decoction (in doses expressed as g crude drug/kg) can be fed orally at 15 g/kg or 25 g/kg to combat sperm damage caused by tripterygium wilfordii for 20 days at 20 mg/kg. Through studies on fertility, it was found that when male mice were administrated with 20mg/kg of Tripterygium wilfordii for 14 days, the number of pregnant female mice could not be significantly reduced, but the number of fetuses in pregnant rats could be significantly reduced. Liuweidihuang Decoction can antagonize the effects of Tripterygium wilfordii on the number of litters by gavage at 15 and 25g/kg, respectively. The disassembled side study showed that: Liuwei Dihuang Tangfang and three diarrhea (Azadirachta, paeonol, Poria), Sanbu (Rehmannia, yam, hawthorn) have obvious effects on the damage of spermatozoa with Tripterygium wilfordii. The three diarrhea had a similar effect with the whole body, but the three supplements were slightly weaker.