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近年来,S-100B蛋白作为脑损伤的神经生化指标,在中枢神经系统损伤的研究中日益受到重视。由于外周血标本易取得,且相对于CT、MRI检查较经济,对于不太适用于伴有意识障碍、人工通气、血流动力学不稳定及不合作的患者,外周血中可以反映脑损伤程度并易于观察其动态变化的神经生化指标,是对临床诊断、治疗、判断预后极好的补充。 一、一般特性 1.S-100B蛋白的结构和分布:S-100蛋白在1965年由Moore于牛脑组织提取液中发现。目前发现S100蛋白是
In recent years, S-100B protein, as a neurobiochemical indicator of brain injury, has drawn more and more attention in the study of central nervous system injury. Due to the availability of peripheral blood samples and the relatively inexpensive MRI compared with CT, peripheral blood can reflect the extent of brain damage and is not suitable for patients with unconsciousness, artificial ventilation, hemodynamic instability and non-cooperation Easy to observe the dynamic changes of neurobiochemical indicators, is an excellent complement to clinical diagnosis, treatment, prognosis. First, the general characteristics 1. S-100B protein structure and distribution: S-100 protein in 1965 by Moore in bovine brain tissue extract found. It is currently found that S100 protein is