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一种广泛应用于医药中间体生产的颗粒状甲叉二乙酯新产品日的在河北枣强县助剂化工厂面世,并投入批量生产。目前我国医药生产中广泛使用的甲叉二乙酯产品大多为液体,由于其性能不稳定,给生产带来诸多影响。去年,该厂与上海有机化工研究所联合对该技术进行攻关并获成功。新型甲叉二乙酯为白色球形颗粒,其产品含量大于99.26%,折光率大,分别比液体产品提高0.5%和10%,且产品收率达到88%以上,经应用于医药氟哌酸产品表明,疗效明显提高。
A kind of granular new product of methylenediate used in the production of pharmaceutical intermediates was introduced in Hebei Zaoqiang County auxiliary chemical plant and put into mass production. At present, most of the products of methylene-diethyl ether widely used in pharmaceutical production in China are liquids, which have many effects on production due to their unstable performance. Last year, the plant and the Shanghai Institute of Organic Chemicals jointly tackled the technology and succeeded. The new methylene diethyl ether is a white spherical particle with a product content of more than 99.26% and a high refractive index, which is 0.5% and 10% higher than that of a liquid product, and a product yield of more than 88%. It has been used in pharmaceutical norfloxacin products. It shows that the efficacy has improved significantly.