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目的研究乾坤胶囊结合高能聚焦超声对原发性肝癌患者的免疫功能影响,并探讨该复方中药制剂抗肝癌的作用机理。方法对90例经细胞病理学证实的原发性肝癌患者,随机分为治疗组30例,对照组30例,空白组30例。从T细胞亚群变化(CD+3、CD+4、CD+8、CD+4CD+8)、NK(自然杀伤细胞)、LAK(淋巴因子激活的杀伤细胞)活性、IL2(白细胞介素2)水平、TGFα(转化生长因子α)的含量变化等方面进行了前瞻性对比治疗研究,并与15例健康人群作比较。结果原发性肝癌患者T细胞亚群紊乱,NK细胞活性、LAK细胞活性、IL2水平低下,TGFα的含量明显升高。与健康人群比较差异有显著性(P<0.01及P<0.05),治疗后各组观察指标有不同程度的回升或降落,与治疗前比较差异有显著性(P<0.01及P<0.05)。治疗后治疗组、空白组的NK细胞活性、LAK细胞活性、IL2水平明显升高,TGFα的含量则显著降低,与对照组比较均有显著性差异(P<0.01及P<0.05);CD+3、CD+4、CD+4CD+8则治疗组优于对照组及空白组(P<0.01及P<0.05)。空白组优于对照组(P<0.05)。结论原发性肝癌患者免疫功能明显低下,乾坤胶囊结合高能聚焦超声可逆转原发性肝癌患者的免疫功能受抑制状态,增强NK细胞、LAK细胞活性,升高IL2水平,降低TGFα的含量。说明乾坤胶囊对HCC患者的预后影响与提高辅助性T细
Objective To study the effect of Qiankun capsule combined with high-energy focused ultrasound on the immune function of patients with primary hepatic carcinoma and to explore the mechanism of action of this compound Chinese herbal preparation against liver cancer. Methods 90 patients with primary hepatocellular carcinoma confirmed by cytopathology were randomly divided into treatment group (30 cases), control group (30 cases) and blank group (30 cases). Changes in T cell subsets (CD + 3, CD + 4, CD + 8, CD + 4CD + 8), NK (natural killer), LAK (lymphokine activated killer) activity, IL2 (interleukin 2 ) Levels, TGFα (transforming growth factor α) content and other aspects of the prospective comparative study of treatment and with 15 healthy people for comparison. Results T cell subgroup disorder, NK cell activity, LAK cell activity and IL2 level were significantly decreased in patients with primary liver cancer, and the content of TGFα was significantly increased. (P <0.01 and P <0.05). After treatment, the observation indexes in all groups had different degrees of rise or fall, which were significantly different from those before treatment (P <0.01 and P <0.05). After treatment, NK cell activity, LAK cell activity and IL2 level in the treatment group and the blank group were significantly increased, the content of TGFα was significantly decreased compared with the control group (P <0.01 and P <0.05) 3, CD + 4, CD + 4CD + 8 treatment group than the control group and the blank group (P <0.01 and P <0.05). The blank group was better than the control group (P <0.05). Conclusion The immune function of patients with primary liver cancer is obviously low. Qiankun capsule combined with high-energy focused ultrasound can reverse the inhibition of immune function in patients with primary liver cancer, enhance the activity of NK cells and LAK cells, increase the level of IL2 and decrease the content of TGFα. Explain Qiankun capsule on the prognosis of HCC patients and improve the T-helper