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目的探讨谷氨酰胺预防胃肠肿瘤术后化疗致肠道损伤的临床效果。方法 46例胃肠道肿瘤术后进行化疗治疗的患者,根据入院治疗的先后顺序将其分成观察组与对照组,各23例。对照组进行化疗治疗时不服用谷氨酰胺,观察组进行化疗治疗联合服用谷氨酰胺,对比两组患者的化疗治疗前后血液中的谷氨酰胺含量,乳果糖/甘露醇浓度(L/M)比值以及化疗不良反应情况。结果观察组患者治疗前后的其血液内的谷氨酰胺的含量明显升高,而对照组患者明显降低,尿中L/M比值情况,对照组在化疗之后明显升高,而观察组患者显著降低,两组比较差异具有统计学意义(P<0.05)。结论在对胃肠肿瘤术后进行化疗时使用谷氨酰胺能够提升患者在化疗之后血液中的谷氨酰胺的浓度,因此可以有效的避免肠道的损伤,因此值得在临床上推广使用。
Objective To investigate the clinical effect of glutamine in preventing postoperative chemotherapy-induced intestinal damage in patients with gastrointestinal neoplasms. Methods Forty-six patients with gastrointestinal cancer treated with chemotherapy were divided into observation group and control group according to the sequence of admission treatment, with 23 cases in each group. The control group did not take glutamine during chemotherapy, the observation group received chemotherapy combined with glutamine. The levels of glutamine, lactulose / mannitol (L / M) in blood before and after chemotherapy were compared between the two groups. Ratio and adverse reactions to chemotherapy. Results Before and after treatment, the content of glutamine in the blood of patients in the observation group was significantly higher than that in the control group, and the ratio of L / M in urine was significantly increased in the control group after chemotherapy and significantly lower in the observation group , The difference between the two groups was statistically significant (P <0.05). Conclusion The use of glutamine in postoperative chemotherapy of gastrointestinal tumors can increase the concentration of glutamine in the blood after chemotherapy. Therefore, it can effectively prevent intestinal damage and is worth popularizing in clinic.