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目的评估喷他佐辛用于小儿术后静脉镇痛的可行性和安全性。方法 150例患儿,ASAⅠ~Ⅱ级随机分为对照组(A)、自控镇痛(DCIA)组(B)、单次给药组(C)3组,记录术后4小时(T1)、8小时(T2)、12小时(T3)、24小时(T4)VAS评分;Ramsay评分;心率(HR)、血压(BP)、呼吸频率(RR)、脉搏氧饱和度(Sp O2)。结果 B组术后各时点疼痛评分逐渐降低,明显低于A、C组(P<0.05),总体印象最佳。3组镇静评分、不良反应发生率无明显差异(P>0.05)。各组各时间点的HR、BP、RR、Sp O2无明显差异(P>0.05)。结论喷他佐辛用于小儿术后PCIA安全、有效。患者术后的总体满意度高且不良反应发生率低。
Objective To evaluate the feasibility and safety of pentazocine for postoperative intravenous analgesia in children. Methods A total of 150 children with ASA Ⅰ ~ Ⅱ were randomly divided into control group (A), DCIA group (B) and single administration group (C) VAS score of 8 hours (T2), 12 hours (T3), 24 hours (T4); Ramsay score; HR, BP, respiratory rate and Sp O2. Results The pain scores of B group decreased gradually after operation, which were significantly lower than those of A and C groups (P <0.05). The overall impression was the best. There was no significant difference in the incidence of adverse reactions between the three groups (P> 0.05). There were no significant differences in HR, BP, RR and Sp O2 between groups at each time point (P> 0.05). Conclusions Pentazocine is safe and effective for PCIA in children. Overall postoperative patient satisfaction and adverse reaction rates were low.