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作者假定,家族因素对肺癌和胃癌的敏感性有一定影响,肺防御机制的个体差异,使个体对吸入香烟敏感性不同,而且与肺癌和胃癌发病也有关系。个体对吸烟所致的肺清除机制损伤颇为敏感,则会在肺内潴留致癌物和其它尘粒,若具有致癌倾向,则会增加肺癌发病的危险性。反之,肺清除机制未受损者可将肺清除的尘粒吞咽入胃,致使有致癌倾向的人有罹患胃癌的危险。肺功能正常者,吸入的尘粒可由粘液纤毛运动清除且无意地被吞咽。例如,一个煤矿工人工作八小时,自大气吸入的尘粒,可使胃的负载高达42mg,而摄入放在同一环境一小时落上尘粒的面包片,胃的负载
The authors hypothesize that familial factors have some effect on the sensitivity of lung and gastric cancers and that individual differences in lung defense mechanisms make individuals susceptible to inhalation of cigarettes and are also associated with the development of lung and gastric cancers. Individuals are quite sensitive to damage caused by smoking lung clearance mechanism, it will retain carcinogens and other dust particles in the lungs, if there is a carcinogenic tendency, it will increase the risk of lung cancer. Conversely, intact lung clearance mechanisms swallow dust particles cleared of the lungs into the stomach, posing a risk of stomach cancer for those with a carcinogenic tendency. Pulmonary function is normal, inhaled dust particles can be cleared by mucociliary movement and inadvertently swallowed. For example, a coal miners working eight hours, inhaled dust particles from the atmosphere, the stomach can load up to 42mg, and intake of the same environment one hour fell dust particles, stomach load