糖尿病心肌病作为糖尿病独立的并发症,舒张功能不全为其早期重要的临床表现,其确切的发病机制尚不明确。目前研究认为,糖尿病心肌病舒张功能不全的病理生理主要表现为Ca2+调节异常、线粒体功能障碍、晚期糖基化终末产物沉积、心肌间质纤维化及心脏自主神经病变等。该文对国内外近年来有关糖尿病心肌病舒张功能不全的临床特点、发病机制及治疗的研究进展予以综述。 Diabetic cardiomyopathy is an independent complication of diabetes. Diastolic dysfunction is an important clinical manifestation in early stage. Its exact pathogenesis is not yet clear. The current study suggests that diabetic cardiomyopathy diastolic dysfunction mainly as the pathophysiology of Ca2 + dysregulation, mitochondrial dysfunction, advanced glycation end products deposition, myocardial interstitial fibrosis and cardiac autonomic neuropathy. This review summarizes the clinical features, pathogenesis and treatment of diastolic dysfunction in diabetic cardiomyopathy at home and abroad in recent years.