Desensitization of G-protein-coupled receptors induces vascular hypocontractility in response to nor

来源 :国际肝胆胰疾病杂志：英文版 | 被引量 : 0次 | 上传用户：chunhuaqiuyue

【摘要】

：

BACKGROUND: The increased β-arrestin-2 and its combination with G-protein-coupled receptors (GPCRs) lead to GPCRs desensitization. The latter may be responsibl

【作者】

：

Wei Chen Jiang-Yong Sang De-Ju

【机构】

：

DepartmentofSurgery,DepartmentofSurgery

【出处】

：

国际肝胆胰疾病杂志：英文版

【发表日期】

：

2013年3期

【关键词】

：

portal hypertension DESENSITIZATION G-protein-coupled receptors β-arrestin-2 RHO

【基金项目】

：

supported by a grant from the National Natural Science Foundation of China (30972920)

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BACKGROUND: The increased β-arrestin-2 and its combination with G-protein-coupled receptors (GPCRs) lead to GPCRs desensitization. The latter may be responsible for decreased contractile reactivity in the mesenteric arteries of cirrhotic patients and rats

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