绪言原发性高血压不是柯兴氏综合症或醛固酮增多症那类典型的内分泌性高血压,发病原理至今不明。虽然,随着肾素测定等检查方法的进展,与肾性高血压的鉴别已逐渐明确,但是否有部分低肾素型原发性高血压和某些盐皮质类固醇有关,现在还缺乏依据。原发性高血压的实验研究以及自发性或遗传性高血压动物模型的运用,到六十年代才逐 INTRODUCTION Essential hypertension is not typical of endocrine hypertension such as Cushing’s syndrome or aldosteronism. The pathogenesis of this disease remains unknown. Although, with the progress of examination methods such as renin determination, and identification of renal hypertension has gradually become clear, but whether some of the low renin type essential hypertension and some mineralocorticoid-related, is still lacking basis. Experimental studies of essential hypertension and the use of animal models of spontaneous or hereditary hypertension were not pursued until the 1960s