目的　探讨喉癌前病变中的DNA含量作为癌变早期分子标志物的临床意义。方法　应用流式细胞术对 80例喉癌前病变组织的DNA含量进行定量检测。结果　 2 9例Ⅰ级不典型增生中出现 1例DNA异倍体 ,30例Ⅱ级不典型增生中出现 2例DNA异倍体 ,2 1例Ⅲ级不典型增生中出现 11例DNA异倍体。结论　喉癌前病变的DNA异倍体出现率随不典型增生病变的分级增高而增加 ,出现DNA异倍体的喉癌前病变的癌变率显著增高 ,DNA异倍体可能是喉癌变早期的分子标志物 Objective To investigate the clinical significance of DNA content in laryngeal precancerous lesions as an early molecular marker of carcinogenesis. Methods The DNA content of 80 precancerous lesions of larynx was quantitatively detected by flow cytometry. Results One case of DNA aneuploidy appeared in 29 cases of grade Ⅰ dysplasia, two cases of DNA aneuploidy in 30 cases of grade Ⅱ dysplasia, and 11 cases of DNA aneuploidy in 21 cases of grade Ⅲ dysplasia . Conclusion The incidence of DNA aneuploidy in pre-laryngeal lesions increases with the grading of atypical hyperplasia lesions. The incidence of carcinogenesis in laryngeal precancerous lesions with DNA aneuploidy is significantly increased. DNA aneuploidy may be the early laryngeal cancer molecule landmark