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为了深入了解肝脏与IgA肾病的关系,给小鼠行肝左叶切除术后14周,发现全部动物肾小球系膜区呈现IgA沉积。进而,本研究应用同位素示踪方法观察到给正常大鼠注入A-IgA(聚合IgA)后0.5小时37.3％为肝脏所摄取;肝左叶切除大鼠在静脉注射A-IgA后24小时血残留量和肾脏沉积显著增加。本实验从宏观上显示了肝脏清除功能在避免IgA肾病中的重要作用,并进一步揭示肝脏与A-IgA的特殊亲和性、肝脏清除功能受损导致IgA肾病的病理生理机制。
In order to gain insight into the relationship between liver and IgA nephropathy, mice were subjected to left hepatectomy for 14 weeks and all animals were found to have IgA deposition in the mesangial area. Furthermore, in this study, 37.3% of the normal rats were injected with A-IgA (polymerized IgA) 0.5 hours after the administration of the liver, and left hepatectomy was performed after 24 hours of intravenous injection of A-IgA. The amount and deposition of kidneys increased significantly. This experiment shows macroscopically the important role of hepatic clearance in avoiding IgA nephropathy, and further reveals the specific affinity of liver and A-IgA, and the pathological and physiological mechanism of IgA nephropathy caused by impaired hepatic clearance.