Objective:To provide an effective treatment for the Osteoarthritis of the hip by observing the effect of local blocking of HongHua injection on relieving hip pain. Methods:Methods from June 2015 to May 2017, 60 patients with Osteoarthritis of the hip in Wangjing Hospital of Chinese Academy of Sciences were randomly divided into treatment group and control group, 30 cases in each group. The treatment group was given local blockingof HongHua injection treatment, control group using Compound Betamethasone Injection local closed treatment. Visual analogue scale (VAS) score, pericoxal local tenderness and hip mobility were used to evaluate the therapeutic effect. The therapeutic indicators at six different time points after 1 days, 3 days, 7 days, 2 weeks and 1 months after treatment were compared. Results:All the 60 cases completed treatment and follow-up, and there were no cases of abscission. There was no significant difference in gender, age, etiology, classification and Harris score before treatment between the two groups (P > 0.05), which was comparable.VAS score:There was no significant difference between the two groups on the 1st, 3rd, 7th and 2nd week after treatment (P > 0.05), but the treatment group was lower than the control group on the 1st month after treatment (P 0.05). Local tenderness around hip:The efficacy of the midpoint inguinal tenderness score was similar between the two groups at 1 day, 7 days, 2 weeks and 1 month after treatment (P >0.05); the treatment group was lower than the control group at 3 days after treatment (P 0.05). Conclusion:Local blockingof HongHua injection is effective and effective in treating hip pain in Osteoarthritis of the hip. The HongHua injection has many advantages, such as good safety and wide indications. It is worthy of further clinical application.