乳腺癌是妇女最常见的恶性肿瘤,目前治疗的重要手段为手术及化疗,但一些患者在化疗前后对某些药物产生耐药性,导致化疗失败,严重影响化疗效果和肿瘤预后。研究发现,肿瘤细胞产生耐药的原因极其复杂。在肿瘤细胞产生耐药的机制中,除了P-gp的“药泵”之外,还存在有 Breast cancer is the most common malignant tumor in women. Currently, the most important means of treatment is surgery and chemotherapy. However, some patients develop resistance to certain drugs before and after chemotherapy, leading to the failure of chemotherapy and seriously affecting the chemotherapy effect and tumor prognosis. The study found that the reasons for tumor drug resistance is extremely complex. In the mechanism of tumor cell resistance, in addition to P-gp “drug pump ”, there are also