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早在１９４０年就有人发现，大脑和垂体的初提物能促成纤维细胞生长。１９８４年，Ｇｏｓｐｏｄａｒｏｗｉｃｚ等〔１〕最先从牛脑中分离出ｂＦＧＦ，其分子量为１６×１０４１ｕ，等电点（ＰＩ）为９６；并发现ｂＦＧＦ能引起Ｂａｌｂ／ｃ３Ｔ３成纤维细胞的增殖与表型转?
As early as 1940, it was found that the brain and pituitary extract can promote fibroblast growth. In 1984, Gospodarowicz et al 〔1〕 first isolated from the bovine brain bFGF, the molecular weight of 1 × 6 × 1041u, the isoelectric point (PI) of 9 6; and found that bFGF can cause Balb / c3T3 fibroblasts Proliferation and Phenotype Turn?