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目的:研究抗早2号方对青春期雌性大鼠骨骼生长的影响和作用机制。方法:120只SD大鼠随机分为治疗组、中药对照组、西药组、空白组4组。用药4周,停药2周,每3周采样1次,观察抗早2号方对青春期雌性大鼠胫骨长度、宽度、骨密度及尿吡啶酚(PYD)和血清I型胶原前胶原C端肽(PICP)的影响。结果:停药2周时,治疗组与空白组比较,血清PICP降低(P<0.05),尿中PYD含量减少(P<0.05),股骨密度、腰椎骨密度、胫骨长径、宽径差异均无统计学意义(P>0.05);与中药对照组比较,血清PICP增高(P<0.05),尿中PYD含量无明显差异(P>0.05),股骨密度显著降低(P<0.01),腰椎骨密度降低(P<0.05);与西药组比较,血清PICP、尿中PYD、股骨和腰椎骨密度、胫骨长径、宽径差异均无统计学意义(P>0.05)。结论:抗早2号方能抑制青春期雌性大鼠骨骼的快速生长,同时维持骨矿含量的稳定。
Objective: To study the effect of Anti-Zaokang Prescription No.2 on skeletal growth of adolescent female rats and its mechanism. Methods: One hundred and twenty SD rats were randomly divided into treatment group, TCM control group, western medicine group and blank control group. After 4 weeks of treatment and 2 weeks of withdrawal, samples were taken every 3 weeks. The effects of Kangzao 2 on the length, width and bone mineral density of the tibia and the changes of urine pyridyl-phenol (PYD) and serum C-type collagen Effect of peptide (PICP). Results: Compared with the blank group, the serum PICP decreased (P <0.05), the content of PYD in urine decreased (P <0.05), the BMD, lumbar BMD, (P> 0.05). Compared with the traditional Chinese medicine control group, the serum PICP increased (P <0.05), the content of PYD in urine had no significant difference (P> 0.05), the femur density decreased significantly (P <0.05). Compared with Western medicine group, the serum PICP, urinary PYD, femur and lumbar BMD, tibia length and width were not significantly different (P> 0.05). Conclusion: Kang-Zao 2 can inhibit the rapid growth of bones in adolescent female rats while maintaining the stability of bone mineral content.