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目的探讨降钙素原(PCT)在慢性阻塞性肺疾病急性加重期患者抗生素使用中的价值。方法将120例患者按随机数字表法分为对照组与PCT组,各60例。PCT组结合PCT检测结果指导患者应用抗生素,对照组则由医师结合患者病情发展判断是否使用抗菌药物,比较两组患者的抗生素使用时间、住院时间、住院费用、治疗效果。结果 PCT组患者的抗生素使用时间、住院时间均明显短于对照组,住院费用明显少于对照组,差异均有统计学意义(均P<0.05);PCT组患者临床治疗总有效率为91.7%,明显高于对照组的75.0%,差异有统计学意义(P<0.05)。结论 PCT可为慢性阻塞性肺疾病急性加重期患者的病因诊断、分层级监测治疗、预后评估提供依据,为抗菌药物的使用提供参考,减少抗生素的使用强度及降低医疗总费用,具有重要的经济及社会效益。
Objective To investigate the value of procalcitonin (PCT) in the use of antibiotics in patients with acute exacerbations of chronic obstructive pulmonary disease. Methods 120 patients were divided into control group and PCT group according to random number table method, each 60 cases. PCT group combined with PCT test results to guide patients with antibiotics, the control group by the patient’s condition to determine whether the use of antimicrobial agents, comparing the two groups of patients antibiotic use time, hospital stay, hospitalization costs, the treatment effect. Results The antibiotic use time and hospitalization time in PCT group were significantly shorter than those in control group, and the hospitalization costs were significantly less than those in control group (all P <0.05). The total effective rate of clinical treatment in PCT group was 91.7% , Significantly higher than 75.0% of the control group, the difference was statistically significant (P <0.05). Conclusion PCT can provide the basis for the etiological diagnosis, hierarchical monitoring and treatment of patients with chronic obstructive pulmonary disease in acute exacerbation, prognosis evaluation, provide a reference for the use of antimicrobial agents, reduce the use of antibiotics and reduce the total cost of medical care, it is important Economic and social benefits.