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为探讨CaNa_2—EDTA不同给药途径与疗效的关系,我们对厚婆坳铅锌矿铅中毒患者及铅吸收工人共20名应用该药物进行了治疗,并作疗效观察。观察对象:慢性轻度铅中毒5例,铅吸收15例。其中男16例,女4例;年龄19～54岁;作业工龄2～29年。治疗前仍接铅。观察项目:临床表现,尿铅(留24小时尿,双硫腙法热消化测定),毒副作用,不同给药途径与疗效的关系等。观察方法:在矿内集中住院治疗,将患者随机抽样分为静脉滴注、肌肉注射二个给药组,每组10例,采用短程间断常规疗法,每日CaNa_2—EDTA1.0克,三天为一疗程,停药四天,再治疗一个疗程,二疗程总剂量为6.0克。还给予甘草绿豆汤、维生素C、卢丁,微量金属合剂等辅助治疗。观察结果:
In order to explore the relationship between the different route of administration of CaNa_2-EDTA and the curative effect, 20 patients with lead poisoning and lead absorption workers from Houpoa lead-zinc mine were treated with this drug and the curative effect was observed. Observed: 5 cases of chronic mild lead poisoning, lead absorption in 15 cases. Including 16 males and 4 females; aged 19 to 54 years; working length of 2 to 29 years. Lead still before treatment. Observations: Clinical manifestations, urinary lead (24-hour urinary retention, thermal dithizone assay), side effects, different routes of administration and efficacy. Observation method: Concentrated hospitalization in the mine, the patients were randomly divided into intravenous drip, intramuscular injection of two treatment groups, 10 patients in each group, using short-routine therapy, daily CaNa 2-EDTA 1.0g, three days For a course of treatment, withdrawal for four days, then a course of treatment, the total dose of two courses of 6.0 grams. Also given licorice mung bean soup, vitamin C, Luding, trace metal mixture and other adjuvant therapy. Observation results: